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Description
TEAD3 His Tag Protein, HumanProduct Specification Species Human Synonyms DTEF1; ETFR 1; ETFR 1; TEAD5; TEF 5 Accession Q99594 Amino Acid Sequence Arg218 Asp435, with N 8*HIS Expression System E. coli Molecular Weight 27kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 20mTris, 300mNaCl, 20% glycerol, 5mM DTT, pH8. 0 Stability & Storage 12 months from date of receipt, lyophilized powder stored
Product Specification
| Species | Human |
| Synonyms | DTEF1; ETFR 1; ETFR 1; TEAD5; TEF 5 |
| Accession | Q99594 |
| Amino Acid Sequence | Arg218-Asp435, with N-8*HIS |
| Expression System | E.coli |
| Molecular Weight | 27kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 20mTris, 300mNaCl, 20% glycerol, 5mM DTT, pH8.0 |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Yi Jin 1, Angela F Messmer-Blust（2011）Trends Cardiovasc Med.21:1 |
Background
The transcriptional enhancer factor (TEF)
multigene family is primarily functional in muscle-specific genes through
binding to MCAT elements that activate or repress transcription of many genes
in response to physiological and pathological stimuli. Among the TEF family,
TEF-1, RTEF-1, and DTEF-1 are critical regulators of cardiac and smooth
muscle-specific genes during cardiovascular development and cardiac disorders
including cardiac hypertrophy. Emerging evidence suggests that in addition to
functioning as muscle-specific transcription factors, members of the TEF family
may be key mediators of gene expression induced by hypoxia in endothelial cells
by virtue of its multidomain organization, potential for post-translational
modifications, and interactions with numerous transcription factors, which represent
a cell-selective control mediator of nuclear signaling.
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